LONDON - GSK plc announced significant overall survival (OS) results from the DREAMM-7 trial, which showed a 42% reduction in the risk of death for patients treated with Blenrep (belantamab mafodotin) in combination with bortezomib and dexamethasone (BVd), compared to a daratumumab-based regimen. The data, presented at the 66th American Society of Hematology (ASH) Annual Meeting, could potentially reshape the standard of care for multiple myeloma patients at or after first relapse.
The trial, which included 494 participants, revealed that the three-year OS rate was 74% in the BVd arm versus 60% in the daratumumab combination arm, with the survival benefit observed as early as four months. Although the median overall survival was not reached in either study arm, projections suggest a median OS of 84 months for BVd, compared to 51 months for the daratumumab combination.
In addition to the OS benefit, the Blenrep combination demonstrated a greater than 2.5-fold improvement in minimal residual disease (MRD) negativity rate, indicating no detectable cancer cells, compared to the daratumumab combination. The results also included improvements in other key secondary efficacy endpoints, such as duration of response (DOR) and progression-free survival 2 (PFS 2), suggesting deeper and more durable responses with BVd.
The safety profile of the Blenrep combination was consistent with previous analyses, with manageable and resolvable eye-related side effects, leading to a low treatment discontinuation rate. The trial's findings build upon earlier results from the DREAMM-7 and DREAMM-8 trials, which demonstrated improvements in progression-free survival.
Regulatory reviews of Blenrep combinations based on the DREAMM-7 and DREAMM-8 trials are underway in several major markets, including the US, European Union, Japan, China, United Kingdom (TADAWUL:4280), Canada, and Switzerland. The DREAMM clinical development program continues to assess the potential of belantamab mafodotin in various treatment combinations and settings.
Multiple myeloma, a blood cancer with high relapse rates, affects a significant number of patients globally, highlighting the need for new, effective treatments. The DREAMM-7 trial results provide promising evidence for Blenrep's role in extending survival for patients with relapsed or refractory multiple myeloma. This report is based on a press release statement.
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