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Pfizer's LORBRENA shows sustained NSCLC patient benefit over five years

Published 06/01/2024, 02:02 AM
© Reuters

NEW YORK - Pfizer Inc. (NYSE: NYSE:PFE) has released new data from its Phase 3 CROWN trial, which shows a significant extension in progression-free survival for patients with ALK-positive advanced non-small cell lung cancer (NSCLC) treated with LORBRENA® (lorlatinib) compared to those treated with XALKORI® (crizotinib).

The findings, presented at the American Society of Clinical Oncology (ASCO) Annual Meeting and published in the Journal of Clinical Oncology, indicate an 81% reduction in the risk of disease progression or death and a 94% reduction in the progression of brain metastases with LORBRENA.

The trial involved 296 individuals with previously untreated ALK-positive advanced NSCLC, who were randomized to receive either LORBRENA monotherapy or XALKORI monotherapy. After a median follow-up of five years, 60% of patients treated with LORBRENA were alive without disease progression, as opposed to only 8% on XALKORI.

Dr. Roger Dansey, Chief Development Officer at Pfizer Oncology, emphasized the significance of these results, stating that they support LORBRENA as a standard of care for the first-line treatment of ALK-positive advanced NSCLC.

The drug was specifically designed to inhibit tumor mutations that drive resistance to other ALK inhibitors and to penetrate the blood-brain barrier, which is critical given that a notable proportion of NSCLC patients develop brain metastases within two years of initial diagnosis.

The safety profile of LORBRENA in the five-year follow-up was consistent with previous findings, with the most frequent adverse events being edema, weight gain, and peripheral neuropathy, among others. Grade 3/4 adverse events occurred in 77% of patients treated with LORBRENA.

Pfizer continues to make efforts to help non-scientists understand the latest findings by developing abstract plain language summaries for company-sponsored research presented at ASCO.

Lung cancer remains the leading cause of cancer-related death globally, with an estimated 234,580 new cases expected in the U.S. in 2024. ALK-positive advanced NSCLC is particularly aggressive and affects a small percentage of lung cancer patients, but these new findings from the CROWN trial represent significant progress in targeted treatment for this patient population.

The information in this article is based on a press release statement from Pfizer Inc.

InvestingPro Insights

Pfizer Inc. (NYSE: PFE) has not only been pioneering in the medical field with its breakthrough treatments but also presents a compelling case for investors looking at its financial health and shareholder returns. With a market capitalization of $159.8 billion, the company stands as a prominent player in the pharmaceutical industry.

InvestingPro Tips highlight that Pfizer has a history of rewarding its shareholders, having raised its dividend for 13 consecutive years and maintained dividend payments for an impressive 54 years. This consistency is reflected in the current dividend yield of 5.96%, which is notably high for the sector. Furthermore, analysts anticipate that Pfizer's net income is expected to grow this year, indicating potential for continued financial strength.

From a valuation perspective, Pfizer's adjusted P/E ratio for the last twelve months as of Q1 2024 is 32.93, which may seem high compared to the industry average; however, this must be balanced against the company's robust dividend payments and expected income growth. Additionally, the company's gross profit margin stands at 59.41%, suggesting efficient operations and a strong competitive position within the market.

For investors interested in further insights and tips, including the fact that Pfizer is trading at a high EBIT and EBITDA valuation multiple, there are additional InvestingPro Tips available at: https://www.investing.com/pro/PFE. With these resources, investors can explore a comprehensive analysis that includes more than 10 additional tips. To gain access to these valuable insights, use coupon code PRONEWS24 to get an additional 10% off a yearly or biyearly Pro and Pro+ subscription.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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